The Duxton Hotel Perth is located on St George's Terrace, the city's business thoroughfare near the Perth Concert Hall and the Swan River.

The hotel’s 306 guest rooms have an in-room executive desk, personal mini-bar, coffee-making facilities, satellite television, on-demand movies, hairdryer, iron and ironing board, full-length mirrors and separate shower and bath in most rooms. Many rooms have superb views over the Swan River Inter-connecting rooms and smoke-free floors are also available. For the business traveler, there is the Club Rooms, on the top two floors of the hotel, with suites and a private Club Lounge facilities and security key lift access.

Hotel facilities include restaurants, bar, Perth's largest hotel fitness center, wet and dry sauna, outdoor heated pool and spa, conference and meeting rooms.